Published: Mitochondrion. 2014; 14: 42-48. doi: 10.1016/j.mito.2013.11.001
Keyword: mitochondial biogenesis, oxidative stress, NIR light, reactive oxygen species, photbiomodulation
Author(s): "Nguyen LM-D, Malamo AG, Larkin-Kaiser KA, Borsa PA, Adhihetty PJ"
Treated C2 C12 murine skeletal muscle cells with different laser doses and measured the activation of AMPK and p38 (mitochondrial biogenesis signaling molecules). They found an optimal activation of these molecules and applied optimal treatment dose over a period of 4 consecutive days. They believe that their study shows that the laser light is capable of altering mitochondrial signaling and regulatory proteins in skeletal muscle tissue without cardiovascular and/or inflammatory influence.