Platelet-Rich Plasma Therapy in Dogs with Bilateral Hip Osteoarthritis

Regenerative Medicine

Platelet-Rich Plasma Therapy in Dogs with Bilateral Hip Osteoarthritis

  • October 4 2023
  • Companion Studies

Published: Alves et al., BMC Veterinary Research (2021) 17:207

Keyword: Dog, Osteoarthritis, Pain, Hip, Platelet-rich plasma, Regenerative therapy

Author(s): J. C. Alves, A. Santos, and P. Jorge

Overview: Osteoarthritis (OA) is the most commonly diagnosed joint disease in companion animals and hip OA is commonly diagnosed in the canine population. The use of platelet-rich plasma has gained increasing interest for the treatment of musculoskeletal conditions in companion animals.


  • To evaluate the effect of the intra-articular administration of platelet-rich plasma in police working dogs with bilateral hip OA compared to a control group.
  • Twenty dogs were assigned to a control group (CG, n = 10) or treatment group (PG, n = 10), using the statistical analysis software.
  •  The sample comprised 20 animals of both sexes (male n = 12, female n = 8), with a mean age of 8.4 ± 2.4 years and a bodyweight of 31.5 ± 5.7 kg.
  • Joints were classified as moderate (13) and severe (7) according to the Orthopedic Foundation for Animals grading scheme.
  • The treatment group received two intra-articular administrations of platelet-rich plasma using the Companion Regenerative Therapies system, 14 days apart.
  • The control group received an intra-articular administration of saline in the same moments.
  • Response to treatment was determined with
    • Canine Brief Pain Inventory
    • Liverpool Osteoarthritis in Dogs
    • Canine Orthopedic Index
    • Hudson Visual Analogue Scale

• These readings were taken before treatment, + 8, + 15, + 30, + 60, + 90, + 120, 150, and + 180 days after initial treatment.


  • Initially, no differences in pain evaluations were found between groups.
  • The treatment group produced better pain scores with longer-lasting results in all evaluations compared to the control group.
  • In some cases, patients in the treatment group had decreased pain response lasting up to the last evaluation moment at 6 months post-injection.

Conclusions: The intra-articular administration of platelet-rich plasma can improve pain and functional scores of police working dogs with bilateral moderate to severe hip OA, compared with a control group. Its effects lasted for significantly longer periods (up to 6 months), and the PRP was:

  • Safe without complications.
  • Used with no additional medications needed during the study period.
  • The utilization of CRT PRP without any additional need for prescription medication makes this PRP product a good therapeutic option for OA management, even in more advanced cases.